Department of Mathematics

Applied Mathematics

  •  Path integral-based inference of PDEs and bond energies and mobility in Dynamic Force Spectroscopy
  •  10/28/2016
  •  4:10 PM - 5:00 PM
  •  C304 Wells Hall
  •  Tom Chou, University of California at Los Angeles

A Bayesian interpretation is given for regularization terms for parameter functions in inverse problems. Fluctuations about the extremal solution depend on the regularization terms - which encode prior knowledge - provide quantification of uncertainty. After reviewing a general path-integral framework, we discuss an application that arises in molecular biophysics: The inference of bond energies and bond coordinate mobilities from dynamic force spectroscopy experiments.



Department of Mathematics
Michigan State University
619 Red Cedar Road
C212 Wells Hall
East Lansing, MI 48824

Phone: (517) 353-0844
Fax: (517) 432-1562

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